Assessment of endogenous intoxication based on the study of medium and low molecular weight substances in patients with myocardial infarction against a background of chronic obstructive pulmonary disease

Introduction . Frequent comorbidity of chronic obstructive pulmonary disease and myocardial infarction is due to the commonality a number etiopathogenetic links development endogenous intoxication syndrome. The convincing markers syndrome are medium low molecular weight molecules including substances oligopeptides. Aim To study levels in patients with against background disease. Materials methods 225 were examined. In 195 developed COPD, 130 – without COPD. comparison group consisted 110 somatically healthy individuals. Substances (MLMWS) oligopeptides (OP) determined by direct spectrometry (according M.Y. Malakhova, 1995) plasma, erythrocytes urine. Endogenous indices coefficient calculated on basis these indices. Statistical processing data was performed using SPSS 26.0 software package. Results blood plasma erythrocytes, average both studied groups statistically significantly higher compared controls. highest detected comorbid patients. 60% examined had phase I intoxication. Phase III prevailed among 62,6%. Conclusions Molecules mass have proven be informative accompanied This opens prospect assessment scales creation prognostic algorithms cardiorespiratory comorbidity.